Oncofetal SALL4-Driven Tumorigenesis Is Highly Dependent on Oxidative Phosphorylation, Revealing Therapeutic Opportunities
نویسندگان
چکیده
منابع مشابه
Oncofetal gene SALL4 in aggressive hepatocellular carcinoma.
BACKGROUND Hepatocellular carcinoma is the third leading cause of cancer-related deaths worldwide. In the heterogeneous group of hepatocellular carcinomas, those with characteristics of embryonic stem-cell and progenitor-cell gene expression are associated with the worst prognosis. The oncofetal gene SALL4, a marker of a subtype of hepatocellular carcinoma with progenitor-like features, is asso...
متن کاملOncofetal Gene SALL4 in Aggressive Hepatocellular Carcinoma
Kol Jia Yong, B.Sc., Chong Gao, M.D., Ph.D., Joline S.J. Lim, M.B., B.S., Benedict Yan, M.B., B.S., Henry Yang, Ph.D., Todor Dimitrov, Ph.D., Akira Kawasaki, M.D., Ph.D., Chee Wee Ong, M.Sc., Kwong-Fai Wong, Ph.D., Sanghoon Lee, Ph.D., Sharada Ravikumar, M.D., Ph.D., Supriya Srivastava, M.D., Xi Tian, B.S., Ronnie T. Poon, M.B., B.S., Ph.D., Sheung Tat Fan, M.D., D.Sc., John M. Luk, D.Med.Sc., ...
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Neuronal oxidative phosphorylation (OXPHOS) deficiency has been associated with a variety of neurodegenerative diseases, including Parkinson's disease and Huntington's disease. However, it is not clear how mitochondrial dysfunction alone can lead to a preferential elimination of certain neuronal populations in vivo. We compared different types of neuronal populations undergoing the same OXPHOS ...
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*Correspondence to: Powel H Brown, Email: [email protected] Submitted: 06/20/13; Accepted: 06/24/13 http://dx.doi.org/10.4161/cc.25871 Comment on: Hartman ZC, et al. Cancer Res 2013; 73:3470-80; PMID:23633491; http://dx.doi.org/10.1158/0008-5472.CAN-12-4524-T Breast cancer is second only to nonmelanoma skin cancers as the most prevalent and lethal malignancy among women worldwide. Upon dia...
متن کاملSALL4 is a novel therapeutic target in intrahepatic cholangiocarcinoma
Intrahepatic cholangiocarcinoma (ICC) is the most common and deadly disease of the biliary tree due to its poor prognosis. Sal-like protein 4 (SALL4), a stem cell marker, has been identified as a potential target for aggressive hepatocellular carcinoma (HCC). In our study, 175 ICC cases with an average age of 55 years were included, and 53% (93/175) were male. And 28 adjacent non-tumor tissues ...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 2019
ISSN: 0016-5085
DOI: 10.1053/j.gastro.2019.09.044